Autoimmune Diseases and Genetics
Autoimmune diseases occur when the immune system fails to distinguish self from non-self, resulting in a breach of tolerance and the likelihood of inflammation or tissue damage in specific organs or multiple organ systems.
Various genetic and environmental factors have been found to contribute to autoimmune disorders. One of the strongest genetic associations is linked to the MHC region and their related gene products, the human leukocyte antigens (HLAs). These HLA’s play a pivotal role in the antigen presentation of self and nonself peptides and the regulation of innate and adaptive immune responses.
DNA Risk HLA-Related Autoimmunity
The comprehensive DNA Risk HLA-Related Autoimmunity (HLA test) looks at gene variants related to common autoimmune diseases and provides healthcare practitioners ‘diagnostic insight’ for patients already suffering from an autoimmune disorder, or who are identified as at risk due to a family history of disease and exposure to environmental risk factors.
The report presents the HLA alleles and genotype data in a user-friendly manner, followed by a brief description of the relevant autoimmune disorders, insights into environmental contributors, and risk (and protective) HLA alleles and MHC-related gene variants related to the disorders.
THE AUTOIMMUNE DISEASES DISCUSSED IN THE REPORT INCLUDE:
- Alopecia areata (AA)
- Ankylosing spondylitis (AS)
- Coeliac disease (CD)
- Graves’ disease (GD)
- Hashimoto thyroiditis (HT)
- IgA nephropathy (IgAN)
- Lyme borreliosis
- Multiple sclerosis (MS)
- Rheumatoid arthritis (RA)
- Systemic lupus erythematosus (SLE)
- Idiopathic membranous nephropathy (IMN)